1. You will either have some special constructed regulating composed disc, cage type or similar, to give support for a complicated and large pressure flow and drop.
If this is the case the answer to your question is more complicated and could be negative.
2. Or you will have,if you are at the other end of the scale, a controlled, slow and laminar flow, and a disc with more of a common flat and compact form. This type of valve is normally used as a typical on/off valve, but in this case used to regulate.
The reason for this is that if you look at this case with incompressible fluids (water) a double offset (double eccentric ) valve will only be properly regulating as long as you have a full pipeline, a low pressure drop, and maintain the flow with a delta over the valve,low enough not to give cavitation.
In addition to this it is commonly known that regulating will only be possible when the valve is at about 20 degrees of opening or less. In addition the regulating will be more coarse than for a proper regulating valve.
If the fluid is gaseous the operation is similar.
If this latter example is relevant, the regulating result could well be within acceptable accuracy with a flow in the 'non preferred direction, - the valve is usually both constructed (and could also be presuure tested) for this.
The problem could more be that 'the wrong direction' is perhaps not tested out for regulating purposes: -flat face against the flow and stem and stem bearings behind in stead of opposite, and it could be difficult or costly to establish flow curves and get the factory to give sufficient back-up and guarantee for the result and problem free (cavitation free) operation if regulating this way.

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